Understanding MGUS as a Risk Factor of Multiple Myeloma
Multiple myeloma damages the immune system with cancer-infected plasma cells. There are various risk factors for multiple myeloma. One of the common reasons that increase the chances of developing multiple myeloma is monoclonal gammopathy of undetermined significance (MGUS). MGUS is caused due to excessive production of abnormal proteins known as M-protein in the blood. These proteins get deposited in the bone marrow and develop to form tumors leading to multiple myeloma. Let us look at the symptoms, causes, and treatment methods for MGUS below. 1. Symptoms MGUS is commonly found in African-American people and older men as compared to caucasians and women. It is considered as one of the major risk factors for multiple myeloma. Not all people affected by MGUS may develop multiple myeloma but all patients with multiple myeloma have had a medical history of MGUS. Most often, the symptoms are not very evident and cannot be experienced at an early stage. However, there are rare chances of experiencing symptoms such as rashes and nerve problems such as numbness and tingling. MGUS can also be detected by blood tests. It is advisable to get a blood check ups done regularly to check protein levels above the age of 60.